Longitudinal variance-components analysis of the Framingham Heart Study data
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چکیده
منابع مشابه
A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines
The Framingham Heart Study is a well known longitudinal cohort study. In recent years, the community-based Framingham Heart Study has embarked on genome-wide association studies. In this paper, we present a Framingham Heart Study genome-wide analysis for fasting triglycerides trait in the Genetic Analysis Workshop16 Problem 2 using multivariate adaptive splines for the analysis of longitudinal ...
متن کاملMultivariate association analysis of the components of metabolic syndrome from the Framingham Heart Study
Metabolic syndrome, by definition, is the manifestation of multiple, correlated metabolic impairments. It is known to have both strong environmental and genetic contributions. However, isolating genetic variants predisposing to such a complex trait has limitations. Using pedigree data, when available, may well lead to increased ability to detect variants associated with such complex traits. The...
متن کاملAortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study.
BACKGROUND Aortic root remodeling in adulthood is known to be associated with cardiovascular outcomes. However, there is a lack of longitudinal data defining the clinical correlates of aortic root remodeling over the adult life course. METHODS AND RESULTS We used serial routine echocardiograms in participants of the Framingham Heart Study to track aortic root diameter over 16 years in mid to ...
متن کاملThe Framingham Heart Study
Previous reports indicate that cardiac output is increased early in the course of hypertension. The purpose of this study was to identify with echocardiography hemodynamic features in normotensive adults that predicted the development of hypertension. Framingham Heart Study subjects were eligible for this investigation if they were normotensive at the baseline examination (systolic blood pressu...
متن کاملThe Framingham Heart Study
Background Sinking prebeta lipoprotein is a putative marker for elevated levels of lipoprotein (a). Although prospective data suggest that increased plasma lipoprotein (a) is an independent risk factor for coronary heart disease in men, no prospective studies are available in women. Methods and Results From 1968 through 1975, sinking prebeta lipoprotein was determined by paper electrophoresis i...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2003
ISSN: 1471-2156
DOI: 10.1186/1471-2156-4-s1-s22